Visualization of ischemic stroke-related changes on ¹⁸F-THK-5351 positron emission tomography.

ABSTRACT:

Background

The ¹⁸F-THK-5351 radiotracer has been used to detect the in vivo tau protein distribution in patients with tauopathy, such as Alzheimer's disease and corticobasal syndrome. In addition, ¹⁸F-THK-5351 can also monitor neuroinflammatory process due to high affinity to astrogliosis. We aimed to explore ¹⁸F-THK-5351 distribution patterns and characteristics in patients with recent ischemic stroke.

Results

Fifteen patients received ¹⁸F-THK-5351 positron emission tomography (PET) and diffusion tensor imaging (DTI) approximately 3 months after ischemic stroke. A region of interest (ROI) was placed in the peri-ischemic area and was mirrored on the contralateral side as the control, and a proportional value was derived from the ra

SUBMITTER: Huang KL 

PROVIDER: S-EPMC6047954 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature