Dentinogenic effects of extracted dentin matrix components digested with matrix metalloproteinases.

ABSTRACT: Dentin is primarily composed of hydroxyapatite crystals within a rich organic matrix. The organic matrix comprises collagenous structural components, within which a variety of bioactive molecules are sequestered. During caries progression, dentin is degraded by acids and enzymes derived from various sources, which can release bioactive molecules with potential reparative activity towards the dentin-pulp complex. While these molecules' repair activities in other tissues are already known, their biological effects are unclear in relation to degradation events during disease in the dentin-pulp complex. This study was undertaken to investigate the effects of dentin matrix components (DMCs) that are partially digested by matrix metalloproteinases (MMPs) in vitro and in vivo during wound healing

SUBMITTER: Okamoto M 

PROVIDER: S-EPMC6048071 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature