Patients with early-stage oropharyngeal cancer can be identified with label-free serum proteomics.

ABSTRACT:

Background

The increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) is mainly related to human papillomavirus (HPV) infection. As OPSCCs are often diagnosed at an advanced stage, mortality and morbidity remain high. There are no diagnostic biomarkers for early detection of OPSCC.

Methods

Serum from 25 patients with stage I-II OPSCC, and 12 healthy controls, was studied with quantitative label-free proteomics using ultra-definition MS^E. Statistical analyses were performed to identify the proteins most reliably distinguishing early-stage OPSCCs from controls. P16 was used as a surrogate marker for HPV. P16-positive and P16-negative tumours were analysed separately.

Results

With two or more unique proteins per identification, 176 proteins were

SUBMITTER: Tuhkuri A 

PROVIDER: S-EPMC6048110 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature