Integrative analysis of oncogenic fusion genes and their functional impact in colorectal cancer.

ABSTRACT:

Background

Fusion genes are good candidates of molecular targets for cancer therapy. However, there is insufficient research on the clinical implications and functional characteristics of fusion genes in colorectal cancer (CRC).

Methods

In this study, we analysed RNA sequencing data of CRC patients (147 tumour and 47 matched normal tissues) to identify oncogenic fusion genes and evaluated their role in CRC.

Results

We validated 24 fusion genes, including novel fusions, by three algorithms and Sanger sequencing. Fusions from most patients were mutually exclusive CRC oncogenes and included tumour suppressor gene mutations. Eleven fusion genes from 13 patients (8.8%) were determined as oncogenic fusion genes by analysing their gene expression and function. To investigate

SUBMITTER: Choi Y 

PROVIDER: S-EPMC6048111 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature