Transient and Persistent UP States during Slow-wave Oscillation and their Implications for Cell-Assembly Dynamics.

ABSTRACT: The membrane potentials of cortical neurons in vivo exhibit spontaneous fluctuations between a depolarized UP state and a resting DOWN state during the slow-wave sleeps or in the resting states. This oscillatory activity is believed to engage in memory consolidation although the underlying mechanisms remain unknown. Recently, it has been shown that UP-DOWN state transitions exhibit significantly different temporal profiles in different cortical regions, presumably reflecting differences in the underlying network structure. Here, we studied in computational models whether and how the connection configurations of cortical circuits determine the macroscopic network behavior during the slow-wave oscillation. Inspired by cortical neurobiology, we modeled three types of synaptic weight distribut

SUBMITTER: Fung CCA 

PROVIDER: S-EPMC6048140 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature