Serotonin concentration enhancers at clinically relevant doses reduce [¹¹C]AZ10419369 binding to the 5-HT_1B receptors in the nonhuman primate brain.

ABSTRACT: The serotonin (5-HT) system plays an important role in the pathophysiology and treatment of several major psychiatric disorders. Currently, no suitable positron emission tomography (PET) imaging paradigm is available to assess 5-HT release in the living human brain. [¹¹C]AZ10419369 binds to 5-HT_1B receptors and is one of the most 5-HT-sensitive radioligands available. This study applied 5-HT concentration enhancers which can be safely studied in humans, and examined their effect on [¹¹C]AZ10419369 binding at clinically relevant doses, including amphetamine (1 mg/kg), 3,4-methylenedioxymethamphetamine (MDMA; 1 mg/kg) or 5-hydroxy-L-tryptophan (5-HTP; 5 mg/kg). Twenty-six PET measurements (14 for amphetamine, 6 for MDMA and 6 for 5-HTP) using a bolus and cons

SUBMITTER: Yang KC 

PROVIDER: S-EPMC6048172 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature