KLF4 suppresses the migration of hepatocellular carcinoma by transcriptionally upregulating monoglyceride lipase.

ABSTRACT: The dysregulation of cellular metabolism, particularly lipid metabolism, is essential for cancer progress. Monoglyceride lipase (MGLL) is an important fatty acid metabolism enzyme, which converts monoacylglycerides to free fatty acids and glycerol. Despite the expression level of MGLL was reported to be downregulated in Hepatocellular carcinoma (HCC), the clinical significances and molecular mechanism of MGLL downregulation remains unknown. In the current study, the clinical significances of MGLL expression were investigated in 95 patients with HCC and the transcription factors of MGLL were identified in HCC cells. We found that MGLL was frequently downregulated in HCC samples, especially in metastatic tumor tissues. Patients with low MGLL expression owned remarkably lower 5 year-overall s

SUBMITTER: Yang X 

PROVIDER: S-EPMC6048399 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature