Ontology highlight
ABSTRACT:
SUBMITTER: Konovalova A
PROVIDER: S-EPMC6048503 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20180625 28
The outer membrane (OM) of Gram-negative bacteria forms a robust permeability barrier that blocks entry of toxins and antibiotics. Most OM proteins (OMPs) assume a β-barrel fold, and some form aqueous channels for nutrient uptake and efflux of intracellular toxins. The Bam machine catalyzes rapid folding and assembly of OMPs. Fidelity of OMP biogenesis is monitored by the σ<sup>E</sup> stress response. When OMP folding defects arise, the proteases DegS and RseP act sequentially to liberate σ<sup ...[more]