Focal, remote-controlled, chronic chemical modulation of brain microstructures.

ABSTRACT: Direct delivery of fluid to brain parenchyma is critical in both research and clinical settings. This is usually accomplished through acutely inserted cannulas. This technique, however, results in backflow and significant dispersion away from the infusion site, offering little spatial or temporal control in delivering fluid. We present an implantable, MRI-compatible, remotely controlled drug delivery system for minimally invasive interfacing with brain microstructures in freely moving animals. We show that infusions through acutely inserted needles target a region more than twofold larger than that of identical infusions through chronically implanted probes due to reflux and backflow. We characterize the dynamics of in vivo infusions using positron emission tomography techniques. Volumes a

SUBMITTER: Ramadi KB 

PROVIDER: S-EPMC6048526 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature