Action potential counting at giant mossy fiber terminals gates information transfer in the hippocampus.

ABSTRACT: Neuronal communication relies on action potential discharge, with the frequency and the temporal precision of action potentials encoding information. Hippocampal mossy fibers have long been recognized as conditional detonators owing to prominent short-term facilitation of glutamate release displayed during granule cell burst firing. However, the spiking patterns required to trigger action potential firing in CA3 pyramidal neurons remain poorly understood. Here, we show that glutamate release from mossy fiber terminals triggers action potential firing of the target CA3 pyramidal neurons independently of the average granule cell burst frequency, a phenomenon we term action potential counting. We find that action potential counting in mossy fibers gates glutamate release over a broad physiolo

SUBMITTER: Chamberland S 

PROVIDER: S-EPMC6048548 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature