Does the 5-HT_1A rs6295 polymorphism influence the safety and efficacy of citalopram therapy in the oldest old?

ABSTRACT: Major depressive disorder (MDD) in older people is a relatively common, yet hard to treat problem. In this study, we aimed to establish if a single nucleotide polymorphism in the 5-HT_1A receptor gene (rs6295) determines antidepressant response in patients aged > 80 years (the oldest old) with MDD. Nineteen patients aged at least 80 years with a new diagnosis of MDD were monitored for response to citalopram 20 mg daily over 4 weeks and genotyped for the rs6295 allele. Both a frequentist and Bayesian analysis was performed on the data. Bayesian analysis answered the clinically relevant question: 'What is the probability that an older patient would enter remission after commencing selective serotonin reuptake inhibitor (SSRI) treatment, conditional on their rs6295 genotype?' Indivi

SUBMITTER: Scutt G 

PROVIDER: S-EPMC6048630 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature