Thiazide Diuretic Dose and Risk of Kidney Stones in Older Adults: A Retrospective Cohort Study.

ABSTRACT:

Background

Thiazide diuretics are commonly prescribed to prevent kidney stones. However, it is unclear whether higher doses confer greater benefit.

Objective

To determine whether lower doses of thiazide diuretics confer a similar protective effect against kidney stone events as higher doses.

Design

Population-based cohort study.

Setting

Linked health administrative databases in Ontario, Canada.

Patients

Older adults newly prescribed a thiazide diuretic between 2003 and 2014 were separated into 2 groups based on daily dose: low dose (⩽12.5 mg hydrochlorothiazide/chlorthalidone, or ⩽1.25 mg indapamide) or high dose.

Measurements

The primary outcome was time to a kidney stone event, using diagnosis and procedure codes. A secondary outcome was kidney

SUBMITTER: Alexander RT 

PROVIDER: S-EPMC6048667 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature