Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer.

ABSTRACT:

Background

The disruption of normal gene regulation due to microRNA dysfunction is a common event in cancer pathogenesis. MicroRNA-27b is an example of an oncogenic miRNA, and it is frequently upregulated in breast cancer. MicroRNAs have been found to deregulate tumor metabolism, which typically manifests as heightened cellular glucose uptake in consort with increased flux through glycolysis, followed by the preferential conversion of glycolytic pyruvate into lactate (a phenomenon known as the Warburg Effect). Pyruvate Dehydrogenase, an enzyme complex linking glycolysis with downstream oxidative metabolism, represents a key location where regulation of metabolism occurs; PDHX is a key structural component of this complex and is essential for its function.

Methods

We sought t

SUBMITTER: Eastlack SC 

PROVIDER: S-EPMC6048708 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature