A gene regulatory network underlying the formation of pre-placodal ectoderm in Xenopus laevis.

ABSTRACT:

Background

The neural plate border ectoderm gives rise to key developmental structures during embryogenesis, including the neural crest and the preplacodal ectoderm. Many sensory organs and ganglia of vertebrates develop from cranial placodes, which themselves arise from preplacodal ectoderm, defined by expression of transcription factor Six1 and its coactivator Eya1. Here we elucidate the gene regulatory network underlying the specification of the preplacodal ectoderm in Xenopus, and the functional interactions among transcription factors that give rise to this structure.

Results

To elucidate the gene regulatory network upstream of preplacodal ectoderm formation, we use gain- and loss-of-function studies to explore the role of early ectodermal transcription factors for esta

SUBMITTER: Maharana SK 

PROVIDER: S-EPMC6048776 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature