Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.

ABSTRACT:

Background

Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the variants identified fall predominantly in non-coding regions and their underlying mechanisms remain unclear.

Results

Here, we identify putative functional coding variation associated with changes in the QRS interval duration by combining Illumina HumanExome BeadChip genotype data from 77,898 participants of European ancestry and 7695 of African descent in our discovery cohort, followed by replication in 111,874 individuals of European ancestry from the UK Biobank and deCODE cohorts. We identify ten novel loci, seven within coding regions, incl

SUBMITTER: Prins BP 

PROVIDER: S-EPMC6048820 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature