MicroRNA expression profiling of goat peripheral blood mononuclear cells in response to peste des petits ruminants virus infection.

ABSTRACT: Peste des petits ruminants virus (PPRV) belongs to the genus Morbillivirus that causes an acute and highly contagious disease in goats and sheep. Virus infection can trigger the change in the cellular microRNA (miRNA) expression profile, which play important post-transcriptional regulatory roles in gene expression and can greatly influence viral replication and pathogenesis. Here, we employed deep sequencing technology to determine cellular miRNA expression profile in goat peripheral blood mononuclear cells (PBMC) infected with Nigeria 75/1 vaccine virus, a widely used vaccine strain for mass vaccination programs against Peste des petits ruminants. Expression analysis demonstrated that PPRV infection can elicit 316 significantly differentially expressed (DE) miRNA including 103 known and 2

SUBMITTER: Qi X 

PROVIDER: S-EPMC6048839 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature