Simulation shows undesirable results for competing risks analysis with time-dependent covariates for clinical outcomes.

ABSTRACT:

Background

We evaluate three methods for competing risks analysis with time-dependent covariates in comparison with the corresponding methods with time-independent covariates.

Methods

We used cause-specific hazard analysis and two summary approaches for in-hospital death: logistic regression and regression of the subdistribution hazard. We analysed real hospital data (n=1864) and considered pneumonia on admission / hospital-acquired pneumonia as time-independent / time-dependent covariates for the competing events 'discharge alive' and 'in-hospital death'. Several simulation studies with time-constant hazards were conducted.

Results

All approaches capture the effect of time-independent covariates, whereas the approaches perform differently with time-dependent covariat

SUBMITTER: Poguntke I 

PROVIDER: S-EPMC6048847 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature