Recombinant FSH Improves Sperm DNA Damage in Male Infertility: A Phase II Clinical Trial.

ABSTRACT: Background and objectives: Male infertility is a global health dilemma and Follicle-Stimulating Hormone (FSH) administration has shown promising results. Several studies showed that infertile men with normal semen parameters have low levels of DNA damage while infertile men with abnormal semen parameters have more damage at the DNA level. Sperm DNA damage may affect the reproductive outcome and has been associated with failure in the achievement of competent embryos and pregnancy fulfillment. The aim of this study was to evaluate whether the administration of recombinant FSH (Gonal-f® PEN 900 IU) could improve sperm DNA fragmentation in men with infertility. The secondary endpoints of this study were to evaluate the FSH effects on sperm parameters and hormonal assets. Methods:

SUBMITTER: Colacurci N 

PROVIDER: S-EPMC6048873 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature