Genetic polymorphisms in the circumsporozoite protein of Plasmodium malariae show a geographical bias.

ABSTRACT:

Background

Plasmodium malariae is characterized by its long asymptomatic persistence in the human host. The epidemiology of P. malariae is incompletely understood and is hampered by the limited knowledge of genetic polymorphisms. Previous reports from Africa have shown heterogeneity within the P. malariae circumsporozoite protein (pmcsp) gene. However, comparative studies from Asian countries are lacking. Here, the genetic polymorphisms in pmcsp of Asian isolates have been characterized.

Methods

Blood samples from 89 symptomatic P. malariae-infected patients were collected, from Thailand (n = 43), Myanmar (n = 40), Lao PDR (n = 5), and Bangladesh (n = 1). pmcsp was amplified using semi-nested PCR before sequencing. The resulting 89 pmcsp sequences were analysed together with

SUBMITTER: Saralamba N 

PROVIDER: S-EPMC6048912 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature