Functional TSPO polymorphism predicts variance in the diurnal cortisol rhythm in bipolar disorder.

ABSTRACT:

Introduction

Psychosocial stress contributes to onset/exacerbation of mood episodes and alcohol use, suggesting dysregulated diurnal cortisol rhythms underlie episodic exacerbations in Bipolar Disorder (BD). However, mechanisms underlying dysregulated HPA rhythms in BD and alcohol use disorders (AUD) are understudied. Knowledge of associated variance factors have great clinical translational potential by facilitating development of strategies to reduce stress-related relapse in BD and AUD. Evidence suggests structural changes to mitochondrial translocator protein (TSPO) (a regulator of steroid synthesis) due to the single nucleotide polymorphism rs6971, may explain much of this variance. However, whether rs6971 is associated with abnormal HPA rhythms and clinical exacerbation in hu

SUBMITTER: Prossin AR 

PROVIDER: S-EPMC6048960 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature