Benefits and Challenges in Using Seroprevalence Data to Inform Models for Measles and Rubella Elimination.

ABSTRACT:

Background

Control efforts for measles and rubella are intensifying globally. It becomes increasingly important to identify and reach remaining susceptible populations as elimination is approached.

Methods

Serological surveys for measles and rubella can potentially measure susceptibility directly, but their use remains rare. In this study, using simulations, we outline key subtleties in interpretation associated with the dynamic context of age-specific immunity, highlighting how the patterns of immunity predicted from disease surveillance and vaccination coverage data may be misleading.

Results

High-quality representative serosurveys could provide a more accurate assessment of immunity if challenges of conducting, analyzing, and interpreting them are overcome. We fram

SUBMITTER: Winter AK 

PROVIDER: S-EPMC6049004 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature