Assessing the functional association of intronic miRNAs with their host genes.

ABSTRACT: In human, nearly half of the known microRNAs (miRNAs) are encoded within the introns of protein-coding genes. The embedment of these miRNA genes within the sequences of protein-coding genes alludes to a possible functional relationship between intronic miRNAs and their hosting genes. Several studies, using predicted targets, suggested that intronic miRNAs influence their hosts' function either antagonistically or synergistically. New experimental data of miRNA expression patterns and targets enable exploring this putative association by relying on actual data rather than on predictions. Here, our analysis based on currently available experimental data implies that the potential functional association between intronic miRNAs and their hosting genes is limited. For host-miRNA examples where

SUBMITTER: Steiman-Shimony A 

PROVIDER: S-EPMC6049507 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature