High-yielding ¹⁸F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo.

ABSTRACT: A novel Al18F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used to demonstrate direct nose-to-brain uptake following intranasal administration, a common yet controversial delivery route for oxytocin-based therapeutics.

SUBMITTER: Beard R 

PROVIDER: S-EPMC6049614 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature