GSTP1 rs1695 is associated with both hematological toxicity and prognosis of ovarian cancer treated with paclitaxel plus carboplatin combination chemotherapy: a comprehensive analysis using targeted resequencing of 100 pharmacogenes.

ABSTRACT:

Purpose

To find genetic variants that predicted toxicity and/or efficacy of paclitaxel plus carboplatin combination therapy (TC therapy).

Patients and methods

In a retrospective case-control study, we analyzed 320 patients who had received TC therapy for gynecological cancers (ovarian, fallopian tube, peritoneal, uterine, and cervical cancers) and collected their germline DNA. We performed a comprehensive pharmacogenomic analysis using a targeted resequencing panel of 100 pharmacogenes. For 1,013 variants passing QC, case-control association studies and survival analyses were conducted.

Results

GSTP1 rs1695 showed the smallest p value for hematotoxicity association, and the ¹⁰⁵Ile wild type allele had a significantly higher risk of severe hematotoxic

SUBMITTER: Yoshihama T 

PROVIDER: S-EPMC6049855 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature