Is local or central adiposity more strongly associated with incident knee osteoarthritis than the body mass index in men or women?

ABSTRACT:

Objective

To determine whether central (abdominal) or peripheral (thigh) adiposity measures are associated with incident radiographic knee osteoarthritis (RKOA) independent of body mass index (BMI) and whether their relation to RKOA was stronger than that of BMI.

Design

161 Osteoarthritis Initiative (OAI) participants (62% female) with incident RKOA (Kellgren/Lawrence grade 0/1 at baseline, developing an osteophyte and joint space narrowing (JSN) grade ≥1 by year-4) were matched to 186 controls (58% female) without incident RKOA. Baseline waist-height-ratio (WHtR), and anatomical cross-sectional areas of thigh subcutaneous (SCF) and intermuscular fat (IMF) were measured, the latter using axial magnetic resonance images. Logistic regression assessed the relationship between e

SUBMITTER: Culvenor AG 

PROVIDER: S-EPMC6050106 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature