A monocyte gene expression signature in the early clinical course of Parkinson's disease.

ABSTRACT: Microglia are the main immune cells of the brain and express a large genetic pattern of genes linked to Parkinson's disease risk alleles. Monocytes like microglia are myeloid-lineage cells, raising the questions of the extent to which they share gene expression with microglia and whether they are already altered early in the clinical course of the disease. To decipher a monocytic gene expression signature in Parkinson's disease, we performed RNA-seq and applied the two-sample Kolmogorov-Smirnov test to identify differentially expressed genes between controls and patients with Parkinson's disease and changes in gene expression variability and dysregulation. The gene expression profiles of normal human monocytes and microglia showed a plethora of differentially expressed genes. Additionally,

SUBMITTER: Schlachetzki JCM 

PROVIDER: S-EPMC6050266 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature