An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets.

ABSTRACT: Klebsiella pneumoniae (Kp) is a globally disseminated opportunistic pathogen that can cause life-threatening infections. It has been found as the culprit of many infection outbreaks in hospital environments, being particularly aggressive towards newborns and adults under intensive care. Many Kp strains produce extended-spectrum β-lactamases, enzymes that promote resistance against antibiotics used to fight these infections. The presence of other resistance determinants leading to multidrug-resistance also limit therapeutic options, and the use of 'last-resort' drugs, such as polymyxins, is not uncommon. The global emergence and spread of resistant strains underline the need for novel antimicrobials against Kp and related bacterial pathogens. To tackle this great challenge, we generated mul

SUBMITTER: Ramos PIP 

PROVIDER: S-EPMC6050338 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature