Ontology highlight
ABSTRACT:
SUBMITTER: Sizemore GM
PROVIDER: S-EPMC6050339 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Nature communications 20180717 1
The importance of the tumor-associated stroma in cancer progression is clear. However, it remains uncertain whether early events in the stroma are capable of initiating breast tumorigenesis. Here, we show that in the mammary glands of non-tumor bearing mice, stromal-specific phosphatase and tensin homolog (Pten) deletion invokes radiation-induced genomic instability in neighboring epithelium. In these animals, a single dose of whole-body radiation causes focal mammary lobuloalveolar hyperplasia ...[more]