Plasmatic Levels of IL-18, IP-10, and Activated CD8⁺ T Cells Are Potential Biomarkers to Identify HIV-1 Elite Controllers With a True Functional Cure Profile.

ABSTRACT: Elite controllers (ECs) are rare individuals able to naturally control HIV-1 replication below the detection limit of viral load (VL) commercial assays. It is unclear, however, whether ECs might be considered a natural model of a functional cure because some studies have noted CD4⁺ T cell depletion and disease progression associated with abnormally high levels of immune activation and/or inflammation in this group. Here, we propose the use of immunological parameters to identify HIV-1 ECs that could represent the best model of a functional cure. We compared plasma levels of six inflammatory biomarkers (IP-10, IL-18, sCD163, sCD14, CRP, and IL-6) and percentages of activated CD8⁺ T cells (CD38⁺HLA-DR⁺) between 15 ECs [8 with persistent undetectabl

SUBMITTER: Cortes FH 

PROVIDER: S-EPMC6050358 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature