Longitudinal structural cerebral changes related to core CSF biomarkers in preclinical Alzheimer's disease: A study of two independent datasets.

ABSTRACT: Alzheimer's disease (AD) is characterized by an accumulation of β-amyloid (Aβ₄₂) accompanied by brain atrophy and cognitive decline. Several recent studies have shown that Aβ₄₂ accumulation is associated with gray matter (GM) changes prior to the development of cognitive impairment, in the so-called preclinical stage of the AD (pre-AD). It also has been proved that the GM atrophy profile is not linear, both in normal ageing but, especially, on AD. However, several other factors may influence this association and may have an impact on the generalization of results from different samples. In this work, we estimate differences in rates of GM volume change in cognitively healthy elders in association with baseline core cerebrospinal fluid (CSF) AD biomarkers, and assess t

SUBMITTER: Falcon C 

PROVIDER: S-EPMC6050455 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature