Sulfonylureas as second line drugs in type 2 diabetes and the risk of cardiovascular and hypoglycaemic events: population based cohort study.

ABSTRACT:

Objective

To assess whether adding or switching to sulfonylureas is associated with an increased risk of myocardial infarction, ischaemic stroke, cardiovascular death, all cause mortality, and severe hypoglycaemia, compared with remaining on metformin monotherapy in patients with type 2 diabetes.

Design

Population based cohort study.

Setting

General practices contributing data to the UK Clinical Practice Research Datalink.

Participants

Patients with type 2 diabetes initiating metformin monotherapy between 1998 and 2013.

Main outcome measures

Using the prevalent new-user cohort design we matched 1:1 patients adding or switching to sulfonylureas with those remaining on metformin monotherapy on high-dimensional propensity score, haemoglobin A1c, and number

SUBMITTER: Douros A 

PROVIDER: S-EPMC6050517 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature