A multifunctional SERS sticky note for real-time quorum sensing tracing and inactivation of bacterial biofilms.

ABSTRACT: Quorum sensing (QS) is crucial for bacterial survival and activity. Although detecting related signaling metabolites can reveal QS, a versatile platform for convenient real-time imaging of their secretion in the context of bacterial biofilms along with inhibition to the growth of biofilms is still highly desired. Here we develop a flexible sticky note with a sandwich structure by encapsulating gold nanostars between two pieces of hexagonal boron nitride layers, which can be easily pasted on natural biofilms to monitor in real-time the secreted signaling molecule by SERS imaging with high sensitivity and spatiotemporal resolution. Using Pseudomonas aeruginosa and its pyocyanin secretion as a model and an internal standard for self-calibration of SERS signals, the sticky note achieves

SUBMITTER: Guo J 

PROVIDER: S-EPMC6050527 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature