Balances: a New Perspective for Microbiome Analysis.

ABSTRACT: High-throughput sequencing technologies have revolutionized microbiome research by allowing the relative quantification of microbiome composition and function in different environments. In this work we focus on the identification of microbial signatures, groups of microbial taxa that are predictive of a phenotype of interest. We do this by acknowledging the compositional nature of the microbiome and the fact that it carries relative information. Thus, instead of defining a microbial signature as a linear combination in real space corresponding to the abundances of a group of taxa, we consider microbial signatures given by the geometric means of data from two groups of taxa whose relative abundances, or balance, are associated with the response variable of interest. In this work we present

SUBMITTER: Rivera-Pinto J 

PROVIDER: S-EPMC6050633 | biostudies-literature | 2018 Jul-Aug

REPOSITORIES: biostudies-literature