Assessing Extracellular Volume in Hemodialysis Patients Using Intradialytic Blood Pressure Slopes.

ABSTRACT: BACKGROUND/AIMS:Extracellular volume (ECV) overload is a mortality risk factor in hemodialysis patients, but no standard approach exists to objectively assess this clinically. We aimed to quantify relationships between slopes of repeated intradialytic blood pressure (BP) measurements and ECV. METHODS:In a cross-sectional study of 71 hemodialysis patients, we calculated BP slopes from all intradialytic measurements using Gaussian regression. We measured extracellular and total body water (TBW) with bioimpedance spectroscopy. We analyzed unconditional and conditional associations between BP slope and volume metrics with mixed linear models and sensitivity analyses using non-linear intradialytic BP trajectory. RESULTS:Mean systolic intradialytic BP slope (IBPS) was -0.06 (0.1) mm Hg/min. Post

SUBMITTER: Liu H 

PROVIDER: S-EPMC6050636 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature