Neuroinflammation in Response to Intracerebral Injections of Different HMGB1 Redox Isoforms.

ABSTRACT:

Background

Neuroinflammation triggered by infection or trauma is the cause of central nervous system dysfunction. High-mobility group box 1 protein (HMGB1), released from stressed and dying brain cells, is a potent neuroinflammatory mediator. The proinflammatory functions of HMGB1 are tightly regulated by post-translational redox modifications, and we here investigated detailed neuroinflammatory responses induced by the individual redox isoforms.

Methods

Male Dark Agouti rats received a stereotactic injection of saline, lipopolysaccharide, disulfide HMGB1, or fully reduced HMGB1, and were accessed for blood-brain barrier modifications using magnetic resonance imaging (MRI) and inflammatory responses by immunohistochemistry.

Results and conclusions

Significant blood-br

SUBMITTER: Aucott H 

PROVIDER: S-EPMC6050639 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature