Lycorine inhibits glioblastoma multiforme growth through EGFR suppression.

ABSTRACT:

Background

Lycorine has been revealed to inhibit the development of many kinds of malignant tumors, including glioblastoma multiforme (GBM). Although compelling evidences demonstrated Lycorine's inhibition on cancers through some peripheral mechanism, in-depth mechanism studies of Lycotine's anti-GBM effects still call for further exploration. Epidermal Growth Factor Receptor (EGFR) gene amplification and mutations are the most common oncogenic events in GBM. Targeting EGFR by small molecular inhibitors is a rational strategy for GBM treatment.

Methods

The molecular docking modeling and in vitro EGFR kinase activity system were employed to identify the potential inhibitory effects of Lycorine on EGFR. And the Biacore assay was used to confirm the direct binding status betwee

SUBMITTER: Shen J 

PROVIDER: S-EPMC6050662 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature