Efficacy, effectiveness and safety of vaccination against human papillomavirus in males: a systematic review.

ABSTRACT:

Background

Human papillomavirus (HPV) vaccination is safe and effective in preventing cervical cancer in females. As HPV infections can also induce cancers of the anus, penis and oral cavity, male vaccination is also advocated, but systematic reviews on efficacy and safety in males are lacking.

Methods

We performed a systematic review on the efficacy, effectiveness and safety of HPV vaccination in males of any age. MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and ClinicalTrials.gov were searched from inception to April 2017.

Results

We identified 5196 articles and seven studies (four randomized controlled trials (RCTs), three non-randomized studies) were included, comprising a total of 5294 participants. Vaccine efficacy against at least 6-month

SUBMITTER: Harder T 

PROVIDER: S-EPMC6050686 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature