Transcriptional network analysis on brains reveals a potential regulatory role of PPP1R3F in autism spectrum disorders.

ABSTRACT:

Objective

This study aims at identifying master regulators of transcriptional networks in autism spectrum disorders (ASDs).

Results

With two sets of independent RNA-Seq data generated on cerebellum from patients with ASDs and control subjects (N = 39 and 45 for set 1, N = 24 and 38 for set 2, respectively), we carried out a network deconvolution of transcriptomic data, followed by virtual protein activity analysis. We identified PPP1R3F (Protein Phosphatase 1 Regulatory Subunit 3F) as a candidate master regulator affecting a large body of downstream genes that are associated with the disease phenotype. Pathway analysis on the identified targets of PPP1R3F in both datasets indicated alteration of endocytosis pathway. Despite a limited sample size, our study represents one of

SUBMITTER: Doostparast Torshizi A 

PROVIDER: S-EPMC6050725 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature