Myocyte-specific overexpressing HDAC4 promotes myocardial ischemia/reperfusion injury.

ABSTRACT: BACKGROUND:Histone deacetylases (HDACs) play a critical role in modulating myocardial protection and cardiomyocyte survivals. However, Specific HDAC isoforms in mediating myocardial ischemia/reperfusion injury remain currently unknown. We used cardiomyocyte-specific overexpression of active HDAC4 to determine the functional role of activated HDAC4 in regulating myocardial ischemia and reperfusion in isovolumetric perfused hearts. METHODS:In this study, we created myocyte-specific active HDAC4 transgenic mice to examine the functional role of active HDAC4 in mediating myocardial I/R injury. Ventricular function was determined in the isovolumetric heart, and infarct size was determined using tetrazolium chloride staining. RESULTS:Myocyte-specific overexpressing activated HDAC4 in mice promot

SUBMITTER: Zhang L 

PROVIDER: S-EPMC6050730 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature