MOG-IgG-associated disease has a stereotypical clinical course, asymptomatic visual impairment and good treatment response.

ABSTRACT:

Objectives

We investigated the clinical characteristics and treatment response in myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease and looked for evidence of subclinical disease.

Methods

We prospectively evaluated the frequency and pattern of relapse, tested afferent visual function and monitored treatment response in 42 south Asian patients from a single centre.

Results

Eighteen patients (42.9%) had monophasic and 24 (57.1%) a relapsing course. Disease duration was longer (P<0.02) in those with a relapsing course. Median time to the second attack was prolonged (P<0.04) in patients with recurrent transverse myelitis when compared with neuromyelitis optica spectrum disorder and recurrent optic neuritis. Thirteen out of 17 patients

SUBMITTER: Pandit L 

PROVIDER: S-EPMC6050870 | biostudies-literature | 2018 Jul-Sep

REPOSITORIES: biostudies-literature