Serum 6-Bromotryptophan Levels Identified as a Risk Factor for CKD Progression.

ABSTRACT: Background Metabolite levels reflect physiologic homeostasis and may serve as biomarkers of disease progression. Identifying metabolites associated with APOL1 risk alleles-genetic variants associated with CKD risk commonly present in persons of African descent-may reveal novel markers of CKD progression relevant to other populations.Methods We evaluated associations between the number of APOL1 risk alleles and 760 serum metabolites identified via untargeted profiling in participants of the African American Study of Kidney Disease and Hypertension (AASK) (n=588; Bonferroni significance threshold P<6.5×10^-5) and replicated findings in 678 black participants with CKD in BioMe, an electronic medical record-linked biobank. We te

SUBMITTER: Tin A 

PROVIDER: S-EPMC6050937 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature