Increased Na_v1.7 expression in the dorsal root ganglion contributes to pain hypersensitivity after plantar incision in rats.

ABSTRACT: Postoperative pain remains a complex problem that is difficult to manage in the clinical context, seriously affecting rehabilitation and the quality of life of patients after surgery. Nociceptors, of which the cell bodies are located in the dorsal root ganglion, are crucial for initiating and conducting the pain signal. The peripheral voltage-gated sodium channels, including Na_v1.7, which is mainly expressed in the dorsal root ganglion, are key to understanding the mechanism underlying postoperative pain. Na_v1.7, in particular, of which mutations in the encoding gene ( SCN9A) can determine whether pain occurs, has aroused most attention. Previous studies have shown that Na_v1.7 in dorsal root ganglion is critical for the development of inflammatory pain and

SUBMITTER: Sun J 

PROVIDER: S-EPMC6050993 | biostudies-literature | 2018 Jan-Dec

REPOSITORIES: biostudies-literature