Antiproliferative and Antimicrobial Activities of Secondary Metabolites and Phylogenetic Study of Endophytic Trichoderma Species From Vinca Plants.

ABSTRACT: Endophytic fungi have been recognized as a potential source of bioactive secondary metabolites. The endophytic Trichoderma species were isolated from Vinca plants (Vinca major, Vinca herbacea, and Vinca minor), found in Iran and screened for antimicrobial and anti-proliferative activity. Based on morphological and phylogenetic analyses, four fungal species were identified: T. asperellum, T. brevicompactum, T. koningiopsis, and T. longibrachiatum. In addition, endophytic fungi bioactivity of methanol and ethyl acetate extracts (7.8-250 μgml^-1) were assessed against a panel of pathogenic fungi and bacteria and IC₈₀ was calculated. Data showed that both methanol and ethyl acetate extracts from all endophytic isolates had significant cyt

SUBMITTER: Leylaie S 

PROVIDER: S-EPMC6051055 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature