Interspecies Anticancer and Antimicrobial Activities of Genus Solanum and Estimation of Rutin by Validated UPLC-PDA Method.

ABSTRACT: Solanaceae is one of the highly diverse plant families of which Solanum is the largest genera (1700 species) containing several pharmacological properties like anticancer and antimicrobial. This motivated us to explore the anticancer (against HepG2, HEK-293, and MCF-7 cells) and antimicrobial (against S. aureus, E. coli, P. aeruginosa, and C. albicans) properties of S. schimperianum, S. villosum, S. coagulans, S. glabratum, S. incanum, and S. nigrum along with rutin estimation by UPLC-PDA method. Of the studied Solanum extracts, S. nigrum exhibited significant cytotoxic property against HepG2 (IC₅₀: 20.4 μg/mL) and MCF-7 (IC₅₀: 30.1 μg/mL); S. coagulans showed toxicity ag

SUBMITTER: Alajmi MF 

PROVIDER: S-EPMC6051100 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature