In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Mycobacterium tuberculosis Clinical Isolates.

ABSTRACT:

Objectives

Evaluating the activity of nineteen β-lactams in combination with different β-lactamase inhibitors to determine the most potent combination against Mycobacterium tuberculosis (MTB) in vitro.

Methods

Drug activity was examined by drug susceptibility test with 122 clinical isolates from China. Mutations of blaC and drug targets ldt_Mt1 , ldt_Mt2 , dacB2, and crfA were analyzed by nucleotide sequencing.

Results

Tebipenem (TBM) in combination with clavulanate (CLA) exhibited the highest anti-TB activity. The MIC of β-lactam antibiotics was reduced most evidently in the presence of CLA, compared to avibactam (AVI) and sulbactam (SUB). Eight polymorphism sites

SUBMITTER: Li F 

PROVIDER: S-EPMC6051288 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature