Longitudinal brain structural alterations in patients with nasopharyngeal carcinoma early after radiotherapy.

ABSTRACT:

Background and purpose

To investigate effects of radiotherapy on normal brain tissue using in vivo neuroimaging in patients with nasopharyngeal carcinoma (NPC).

Methods and materials

We used longitudinal MRI to monitor structural brain changes during standard radiotherapy in patients newly diagnosed with NPC. We assessed volumetric measures in 63 patients at 2-3 time points before and after radiotherapy, with 20 NPC-free participants as normal controls. Images were processed using validated software (FreeSurfer). Automated results were inspected visually for accuracy. We examined changes in volume of the whole brain, gray matter, white matter, and ventricles, as well as in cerebral volumes partitioned into temporal, frontal, parietal, and occipital lobes. A linear mixed mode

SUBMITTER: Guo Z 

PROVIDER: S-EPMC6051477 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature