Antimargination of Microparticles and Platelets in the Vicinity of Branching Vessels.

ABSTRACT: We investigate the margination of microparticles/platelets in blood flow through complex geometries typical for in vivo vessel networks: a vessel confluence and a bifurcation. Using three-dimensional lattice Boltzmann simulations, we confirm that behind the confluence of two vessels, a cell-free layer devoid of red blood cells develops in the channel center. Despite its small size of roughly 1 μm, this central cell-free layer persists for up to 100 μm after the confluence. Most importantly, we show from simulations that this layer also contains a significant amount of microparticles/platelets and validate this result by in vivo microscopy in mouse venules. At bifurcations, however, a similar effect does not appear, and margination is largely unaffected by the geometry. This antimargination

SUBMITTER: Bacher C 

PROVIDER: S-EPMC6051480 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature