Stratification of MDD and GAD patients by resting state brain connectivity predicts cognitive bias.

ABSTRACT: Patients with Generalized Anxiety Disorder (GAD) and Major Depressive Disorder (MDD) show between-group comorbidity and symptom overlap, and within-group heterogeneity. Resting state functional connectivity might provide an alternate, biologically informed means by which to stratify patients with GAD or MDD. Resting state functional magnetic resonance imaging data were acquired from 23 adults with GAD, 21 adults with MDD, and 27 healthy adult control participants. We investigated whether within- or between-network connectivity indices from five resting state networks predicted scores on continuous measures of depression and anxiety. Successful predictors were used to stratify participants into two new groups. We examined whether this stratification predicted attentional bias towards threat

SUBMITTER: Bijsterbosch JD 

PROVIDER: S-EPMC6051497 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature