Advances in the Genetics of Youth-Onset Type 2 Diabetes.

ABSTRACT:

Purpose of review

To provide an update on knowledge the role of genetics in youth-onset type 2 diabetes (T2D).

Recent findings

The prevalence in youth of T2D, once thought to be exclusively a disease of adults, has increased by over 35% since 2001. Youth with T2D tend to have higher rates of complications, more aggressive disease, with more rapid loss of beta-cell function and a less favorable response to treatment than adults. Obesity is the most important risk factor for T2D, and the rise in childhood overweight and obesity appears responsible for the dramatic increase in T2D in youth. However, some obese children do not develop T2D, consistent with genetic differences in susceptibility to the disease in the setting of obesity and insulin resistance, currently far less wel

SUBMITTER: Todd JN 

PROVIDER: S-EPMC6051541 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature