Diurnal oscillations in human salivary microRNA and microbial transcription: Implications for human health and disease.

ABSTRACT: The microbiome plays a vital role in human health and disease. Interaction between human hosts and the microbiome occurs through a number of mechanisms, including transcriptomic regulation by microRNA (miRNA). In animal models, circadian variations in miRNA and microbiome elements have been described, but patterns of co-expression and potential diurnal interaction in humans have not. We investigated daily oscillations in salivary miRNA and microbial RNA to explore relationships between these components of the gut-brain-axis and their implications in human health. Nine subjects provided 120 saliva samples at designated times, on repeated days. Samples were divided into three sets for exploration and cross-validation. Identification and quantification of host miRNA and microbial RNA was perf

SUBMITTER: Hicks SD 

PROVIDER: S-EPMC6051604 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature